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10.1021/acs.jmedchem.5b00417 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.5b00417 C4854205!4854205 !26125082     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26125082 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Chem 2015 ; 58 (21 ): 8360-72 Nephropedia Template TP {{tp|p=26125082 |t=2015. Development of Safe and Effective Botanical Dietary Supplements |pdf=|usr=}}{{26125082 }} gab.com Text Development of Safe and Effective Botanical Dietary Supplements JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26125082 #FOAvip Regulated differently than drugs or foods, the market for botanical dietary supplements continues to grow worldwide. The recently implemented U.S. FDA regulation that all botanical dietary supplements must be produced using good manufacturing practice is an important step toward enhancing the safety of these products, but additional safeguards could be implemented, and unlike drugs, there are currently no efficacy requirements. To ensure a safe and effective product, botanical dietary supplements should be developed in a manner analogous to pharmaceuticals that involves identification of mechanisms of action and active constituents, chemical standardization based on the active compounds, biological standardization based on pharmacological activity, preclinical evaluation of toxicity and potential for drug-botanical interactions, metabolism of active compounds, and finally, clinical studies of safety and efficacy. Completing these steps will enable the translation of botanicals from the field to safe human use as dietary supplements. Twit Text FOAVip Development of Safe and Effective Botanical Dietary Supplements ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26125082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26125082 #FOAvip English Wikipedia <ref>{{Cite pmid|26125082 }}</ref> Development of Safe and Effective Botanical Dietary Supplements #MMPMID26125082 van Breemen RB J Med Chem 2015[Nov]; 58 (21 ): 8360-72 PMID26125082 show ga Regulated differently than drugs or foods, the market for botanical dietary supplements continues to grow worldwide. The recently implemented U.S. FDA regulation that all botanical dietary supplements must be produced using good manufacturing practice is an important step toward enhancing the safety of these products, but additional safeguards could be implemented, and unlike drugs, there are currently no efficacy requirements. To ensure a safe and effective product, botanical dietary supplements should be developed in a manner analogous to pharmaceuticals that involves identification of mechanisms of action and active constituents, chemical standardization based on the active compounds, biological standardization based on pharmacological activity, preclinical evaluation of toxicity and potential for drug-botanical interactions, metabolism of active compounds, and finally, clinical studies of safety and efficacy. Completing these steps will enable the translation of botanicals from the field to safe human use as dietary supplements. |*Drug Discovery/methods [MESH] |Animals [MESH] |Biological Products/*adverse effects/metabolism/pharmacokinetics/toxicity [MESH] |Clinical Trials as Topic/methods [MESH] |Dietary Supplements/*adverse effects/toxicity [MESH] |Drug Evaluation, Preclinical/methods [MESH] |Humans [MESH]Development of Safe and Effective Botanical Dietary Supplements (epmc).pdf DeepDyve Pubget Overpricing