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2015 ; 3
(ä): 53
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Developing a functional urinary bladder: a neuronal context
#MMPMID26389118
Keast JR
; Smith-Anttila CJ
; Osborne PB
Front Cell Dev Biol
2015[]; 3
(ä): 53
PMID26389118
show ga
The development of organs occurs in parallel with the formation of their nerve
supply. The innervation of pelvic organs (lower urinary tract, hindgut, and
sexual organs) is complex and we know remarkably little about the mechanisms that
form these neural pathways. The goal of this short review is to use the urinary
bladder as an example to stimulate interest in this question. The bladder
requires a healthy mature nervous system to store urine and release it at
behaviorally appropriate times. Understanding the mechanisms underlying the
construction of these neural circuits is not only relevant to defining the basis
of developmental problems but may also suggest strategies to restore connectivity
and function following injury or disease in adults. The bladder nerve supply
comprises multiple classes of sensory, and parasympathetic or sympathetic
autonomic effector (motor) neurons. First, we define the developmental endpoint
by describing this circuitry in adult rodents. Next we discuss the innervation of
the developing bladder, identifying challenges posed by this area of research.
Last we provide examples of genetically modified mice with bladder dysfunction
and suggest potential neural contributors to this state.
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