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10.1186/s13742-015-0081-6 http://scihub22266oqcxt.onion/10.1186/s13742-015-0081-6 C4570224!4570224 !26380078     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26380078 &cmd=llinks): Failed to open stream: HTTP request failed! 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Determination of nonlinear genetic architecture using compressed sensing |pdf=|usr=}}{{26380078 }} gab.com Text Determination of nonlinear genetic architecture using compressed sensing JO: Gigascience http://www.kidney.de/pget.php?&tw=1&pmid=26380078 #FOAvip BACKGROUND: One of the fundamental problems of modern genomics is to extract the genetic architecture of a complex trait from a data set of individual genotypes and trait values. Establishing this important connection between genotype and phenotype is complicated by the large number of candidate genes, the potentially large number of causal loci, and the likely presence of some nonlinear interactions between different genes. Compressed Sensing methods obtain solutions to under-constrained systems of linear equations. These methods can be applied to the problem of determining the best model relating genotype to phenotype, and generally deliver better performance than simply regressing the phenotype against each genetic variant, one at a time. We introduce a Compressed Sensing method that can reconstruct nonlinear genetic models (i.e., including epistasis, or gene-gene interactions) from phenotype-genotype (GWAS) data. Our method uses L1-penalized regression applied to nonlinear functions of the sensing matrix. RESULTS: The computational and data resource requirements for our method are similar to those necessary for reconstruction of linear genetic models (or identification of gene-trait associations), assuming a condition of generalized sparsity, which limits the total number of gene-gene interactions. An example of a sparse nonlinear model is one in which a typical locus interacts with several or even many others, but only a small subset of all possible interactions exist. It seems plausible that most genetic architectures fall in this category. We give theoretical arguments suggesting that the method is nearly optimal in performance, and demonstrate its effectiveness on broad classes of nonlinear genetic models using simulated human genomes and the small amount of currently available real data. A phase transition (i.e., dramatic and qualitative change) in the behavior of the algorithm indicates when sufficient data is available for its successful application. CONCLUSION: Our results indicate that predictive models for many complex traits, including a variety of human disease susceptibilities (e.g., with additive heritability h (2)?0.5), can be extracted from data sets comprised of n ??100s individuals, where s is the number of distinct causal variants influencing the trait. For example, given a trait controlled by ?10 k loci, roughly a million individuals would be sufficient for application of the method. Twit Text FOAVip Determination of nonlinear genetic architecture using compressed sensing ????Gigascience http://www.kidney.de/pget.php?&tw=1&pmid=26380078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26380078 #FOAvip English Wikipedia <ref>{{Cite pmid|26380078 }}</ref> Determination of nonlinear genetic architecture using compressed sensing #MMPMID26380078 Ho CM ; Hsu SD Gigascience 2015[]; 4 (ä): 44 PMID26380078 show ga BACKGROUND: One of the fundamental problems of modern genomics is to extract the genetic architecture of a complex trait from a data set of individual genotypes and trait values. Establishing this important connection between genotype and phenotype is complicated by the large number of candidate genes, the potentially large number of causal loci, and the likely presence of some nonlinear interactions between different genes. Compressed Sensing methods obtain solutions to under-constrained systems of linear equations. These methods can be applied to the problem of determining the best model relating genotype to phenotype, and generally deliver better performance than simply regressing the phenotype against each genetic variant, one at a time. We introduce a Compressed Sensing method that can reconstruct nonlinear genetic models (i.e., including epistasis, or gene-gene interactions) from phenotype-genotype (GWAS) data. Our method uses L1-penalized regression applied to nonlinear functions of the sensing matrix. RESULTS: The computational and data resource requirements for our method are similar to those necessary for reconstruction of linear genetic models (or identification of gene-trait associations), assuming a condition of generalized sparsity, which limits the total number of gene-gene interactions. An example of a sparse nonlinear model is one in which a typical locus interacts with several or even many others, but only a small subset of all possible interactions exist. It seems plausible that most genetic architectures fall in this category. We give theoretical arguments suggesting that the method is nearly optimal in performance, and demonstrate its effectiveness on broad classes of nonlinear genetic models using simulated human genomes and the small amount of currently available real data. A phase transition (i.e., dramatic and qualitative change) in the behavior of the algorithm indicates when sufficient data is available for its successful application. CONCLUSION: Our results indicate that predictive models for many complex traits, including a variety of human disease susceptibilities (e.g., with additive heritability h (2)?0.5), can be extracted from data sets comprised of n ??100s individuals, where s is the number of distinct causal variants influencing the trait. For example, given a trait controlled by ?10 k loci, roughly a million individuals would be sufficient for application of the method. |*Models, Genetic [MESH] |Algorithms [MESH]Determination of nonlinear genetic architecture using compressed sensi(epmc).pdf DeepDyve Pubget Overpricing