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2016 ; 38
(1
): 14-20
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Detection of autoantibodies using chemiluminescence technologies
#MMPMID26525648
Mahler M
; Bentow C
; Serra J
; Fritzler MJ
Immunopharmacol Immunotoxicol
2016[]; 38
(1
): 14-20
PMID26525648
show ga
CONTEXT: Although autoantibody detection methods such as indirect
immunofluorescence (IIF) and enzyme-linked immunosorbent assays (ELISAs) have
been available for many years and are still in use the innovation of fast, fully
automated instruments using chemiluminescence technology in recent years has led
to rapid adoption in autoimmune disease diagnostics. In 2009, BIO-FLASH, a fully
automated, random access chemiluminescent analyzer, was introduced, proceeded by
the development of the QUANTA Flash chemiluminescent immunoassays (CIA) for
autoimmune diagnostics. OBJECTIVE: To summarize the evolution of CIAs for the
detection of autoantibodies and to review their performance characteristics.
METHODS: Pubmed was screened for publications evaluating novel QUANTA Flash
assays and how they compare to traditional methods for the detection of
autoantibodies. In addition, comparative studies presented at scientific meetings
were summarized. RESULTS: Several studies were identified that compared the novel
CIAs with conventional methods for autoantibody detection. The agreements ranged
from moderate to excellent depending on the assay. The studies show how the CIA
technology has enhanced the analytical and clinical performance characteristics
of many autoantibody assays supporting both diagnosis and follow-up testing.
CONCLUSION: CIA has started to improve the diagnostic testing of autoantibodies
as an aid in the diagnosis of a broad range of autoimmune diseases.
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