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2018 ; 6
(2
): e00291
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Desquamative interstitial pneumonia complicated by diffuse alveolar haemorrhage
#MMPMID29321935
Matsuo A
; Matsumoto N
; Kitamura A
; Tsubouchi H
; Yanagi S
; Nakazato M
Respirol Case Rep
2018[Feb]; 6
(2
): e00291
PMID29321935
show ga
We report a rare case of desquamative interstitial pneumonia (DIP) with diffuse
alveolar haemorrhage (DAH). A 56-year-old man diagnosed with DIP by surgical lung
biopsy 2 years ago was admitted to our hospital because of severe acute
respiratory failure. The DIP had progressed despite smoking cessation. On
admission, the patient appeared extremely ill, and physical examination revealed
respiratory distress. The patient required mechanical ventilation.
High-resolution computed tomography showed diffuse ground glass opacity in both
lungs. The bronchoalveolar lavage fluid was bloody, and numerous
haemosiderin-laden alveolar macrophages were detected. Pulse steroid therapy
followed by oral prednisolone immediately relieved the respiratory failure and
improved the long-term control of the DIP. Paired sera tests confirmed the
diagnosis of influenza A/H3N2 virus infection, which was the cause of the DAH.
Chronically progressive DIP with acute respiratory failure due to DAH was
successfully treated by steroid therapy.