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2014 ; 50
(99
): 15651-68
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Design of growth factor sequestering biomaterials
#MMPMID25182455
Belair DG
; Le NN
; Murphy WL
Chem Commun (Camb)
2014[Dec]; 50
(99
): 15651-68
PMID25182455
show ga
Growth factors (GFs) are major regulatory proteins that can govern cell fate,
migration, and organization. Numerous aspects of the cell milieu can modulate
cell responses to GFs, and GF regulation is often achieved by the native
extracellular matrix (ECM). For example, the ECM can sequester GFs and thereby
control GF bioavailability. In addition, GFs can exert distinct effects depending
on whether they are sequestered in solution, at two-dimensional interfaces, or
within three-dimensional matrices. Understanding how the context of GF
sequestering impacts cell function in the native ECM can instruct the design of
soluble or insoluble GF sequestering moieties, which can then be used in a
variety of bioengineering applications. This Feature Article provides an overview
of the natural mechanisms of GF sequestering in the cell milieu, and reviews the
recent bioengineering approaches that have sequestered GFs to modulate cell
function. Results to date demonstrate that the cell response to GF sequestering
depends on the affinity of the sequestering interaction, the spatial proximity of
sequestering in relation to cells, the source of the GF (supplemented or
endogenous), and the phase of the sequestering moiety (soluble or insoluble). We
highlight the importance of context for the future design of biomaterials that
can leverage endogenous molecules in the cell milieu and mitigate the need for
supplemented factors.
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