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2016 ; 45
(ä): 85-116
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Design Principles of Length Control of Cytoskeletal Structures
#MMPMID27145876
Mohapatra L
; Goode BL
; Jelenkovic P
; Phillips R
; Kondev J
Annu Rev Biophys
2016[Jul]; 45
(ä): 85-116
PMID27145876
show ga
Cells contain elaborate and interconnected networks of protein polymers, which
make up the cytoskeleton. The cytoskeleton governs the internal positioning and
movement of vesicles and organelles and controls dynamic changes in cell
polarity, shape, and movement. Many of these processes require tight control of
the size and shape of cytoskeletal structures, which is achieved despite rapid
turnover of their molecular components. Here we review mechanisms by which cells
control the size of filamentous cytoskeletal structures, from the point of view
of simple quantitative models that take into account stochastic dynamics of their
assembly and disassembly. Significantly, these models make experimentally
testable predictions that distinguish different mechanisms of length control.
Although the primary focus of this review is on cytoskeletal structures, we
believe that the broader principles and mechanisms discussed herein will apply to
a range of other subcellular structures whose sizes are tightly controlled and
are linked to their functions.
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