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2011 ; 3
(1
): 47-52
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Deriving biomedical diagnostics from NMR spectroscopic data
#MMPMID28510234
Smith ICP
; Somorjai RL
Biophys Rev
2011[Mar]; 3
(1
): 47-52
PMID28510234
show ga
Biomedical spectroscopic experiments generate large volumes of data. For
accurate, robust diagnostic tools the data must be analyzed for only a few
characteristic observations per subject, and a large number of subjects must be
studied. We describe here two of the current data analytic approaches applied to
this problem: SIMCA (principal component analysis, partial least squares), and
the statistical classification strategy (SCS). We demonstrate the application of
the SCS by three examples of its use in analyzing (1)H NMR spectra: screening for
colon cancer, characterization of thyroid cancer, and distinguishing cancer from
cholangitis in the biliary tract.