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10.1096/fj.14-251249 http://scihub22266oqcxt.onion/10.1096/fj.14-251249 C5395721!5395721 !24928192     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24928192 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24928192 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FASEB+J 2014 ; 28 (9 ): 3832-40 Nephropedia Template TP {{tp|p=24928192 |t=2014. Deoxyribonucleotides as genetic and metabolic regulators |pdf=|usr=}}{{24928192 }} gab.com Text Deoxyribonucleotides as genetic and metabolic regulators JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=24928192 #FOAvip For >35 yr, we have known that the accuracy of DNA replication is controlled in large part by the relative concentrations of the 4 canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the replisome. Since this field was last reviewed, ?8 yr ago, there has been increased understanding of the mutagenic pathways as they occur in living cells. At the same time, aspects of deoxyribonucleotide metabolism have been shown to be critically involved in processes as diverse as cell cycle control, protooncogene expression, cellular defense against HIV infection, replication rate control, telomere length control, and mitochondrial function. Evidence supports a relationship between dNTP pools and microsatellite repeat instability. Relationships between dNTP synthesis and breakdown in controlling steady-state pools have become better defined. In addition, new experimental approaches have allowed definitive analysis of mutational pathways induced by dNTP pool abnormalities, both in Escherichia coli and in yeast. Finally, ribonucleoside triphosphate (rNTP) pools have been shown to be critical determinants of DNA replication fidelity. These developments are discussed in this review article. Twit Text FOAVip Deoxyribonucleotides as genetic and metabolic regulators ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=24928192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24928192 #FOAvip English Wikipedia <ref>{{Cite pmid|24928192 }}</ref> Deoxyribonucleotides as genetic and metabolic regulators #MMPMID24928192 Mathews CK FASEB J 2014[Sep]; 28 (9 ): 3832-40 PMID24928192 show ga For >35 yr, we have known that the accuracy of DNA replication is controlled in large part by the relative concentrations of the 4 canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the replisome. Since this field was last reviewed, ?8 yr ago, there has been increased understanding of the mutagenic pathways as they occur in living cells. At the same time, aspects of deoxyribonucleotide metabolism have been shown to be critically involved in processes as diverse as cell cycle control, protooncogene expression, cellular defense against HIV infection, replication rate control, telomere length control, and mitochondrial function. Evidence supports a relationship between dNTP pools and microsatellite repeat instability. Relationships between dNTP synthesis and breakdown in controlling steady-state pools have become better defined. In addition, new experimental approaches have allowed definitive analysis of mutational pathways induced by dNTP pool abnormalities, both in Escherichia coli and in yeast. Finally, ribonucleoside triphosphate (rNTP) pools have been shown to be critical determinants of DNA replication fidelity. These developments are discussed in this review article. |*DNA Replication [MESH] |*Gene Expression Regulation [MESH] |*Mutagenesis [MESH] |Animals [MESH] |Deoxyribonucleotides/*metabolism [MESH] |Humans [MESH]Deoxyribonucleotides as genetic and metabolic regulators (epmc).pdf DeepDyve Pubget Overpricing