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2015 ; 10
(3
): 169-72
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Delta hepatitis-related thyroid disease: a unique phenomenon
#MMPMID26516384
Suvak B
; Dulger AC
; Aykaç MC
; Gonullu H
; Gonullu E
Prz Gastroenterol
2015[]; 10
(3
): 169-72
PMID26516384
show ga
INTRODUCTION: Hepatitis delta virus (HDV) infection is a serious health problem
worldwide. Thyroid disturbances represent a major limitation to the efficacy of
interferon treatment targeting chronic HDV (C-HDV) infection. Moreover,
pre-treatment thyroid diseases may be influenced by interferon therapy. Despite
this, the characteristic features of the thyroid diseases in C-HDV patients
remain poorly characterised. AIM: To determine the prevalence of thyroid diseases
and evaluate the impact of delta hepatitis on thyroid function tests. MATERIAL
AND METHODS: We retrospectively reviewed the charts of 127 hepatitis C virus
(HCV)-negative adults, treatment-naive outpatients with C-HDV, between July 2013
and July 2014. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAbs)
including anti-thyroid peroxidase antibodies (anti-TPO), liver transaminases, and
other routine laboratory tests were conducted during the study period. RESULTS: A
total of 127 C-HDV patients (female 52.9%, mean age 54.5 ±8.01 years) were
enrolled. The rate of hypothyroidism, defined as a TSH level above 10 IU/l, was
4.7%. No patient had hyperthyroidism. Both elevated levels of liver transaminases
and HDV ribonucleic acid (HDV-RNA) were positively correlated with high levels of
thyroid autoantibodies. CONCLUSIONS: The rate of hypothyroidism is higher than
the rate of hyperthyroidism at baseline. Most remarkably, for the first time we
discovered a correlation between disturbed thyroid autoantibodies and elevated
liver transaminases as well as high HDV-RNA levels even in euthyroid delta
hepatitis patients. But in order to have an adequate understanding of such
correlations, further studies are needed.
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