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Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis
#MMPMID27252943
Sfera A
; Cummings M
; Osorio C
Front Mol Biosci
2016[]; 3
(?): 18
PMID27252943
show ga
Dehydration is one of the ten most frequent diagnoses responsible for the
hospital admission of elderly in the United States. It is associated with
increased mortality, morbidity and an estimated cost of 1.14 billion per year
(Xiao et al., 2004; Schlanger et al., 2010; Pretorius et al., 2013; Frangeskou et
al., 2015). Older individuals are predisposed to dehydration encephalopathy as a
result of decreased total body water (TBW) and diminished sensation of thirst. We
hypothesize that thirst blunting in older individuals is the result of a
defective microRNA-6842-3p failing to silence the expression of the vesicular
GABA transporters (VGAT) and alpha 7 cholinergic nicotinic receptors in the
subfornical organ (SFO) of the hypothalamus. We hypothesize further that
resultant dehydration facilitates protein misfolding and aggregation,
predisposing to neurocognitive disorders. We completed a search of predicted
microRNA targets, utilizing the public domain tool miRDB and found that
microRNA-6842-3p modulates the SLC6A1 and CHRNA7 genes both of which were
previously hypothesized to inhibit the thirst sensation by their action on SFO.
The primary aim of this article is to answer two questions: Can prevention and
correction of dehydration in elderly lower age-related cognitive deterioration?
Can exosomal miR-6842 in the peripheral blood predict dehydration encephalopathy
in elderly?
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