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2014 ; 588
(8
): 1221-9
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Degradation of connexins and gap junctions
#MMPMID24486527
Falk MM
; Kells RM
; Berthoud VM
FEBS Lett
2014[Apr]; 588
(8
): 1221-9
PMID24486527
show ga
Connexin proteins are short-lived within the cell, whether present in the
secretory pathway or in gap junction plaques. Their levels can be modulated by
their rate of degradation. Connexins, at different stages of assembly, are
degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways.
In this review, we summarize the current knowledge about connexin and gap
junction degradation including the signals and protein-protein interactions that
participate in their targeting for degradation.