Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16776585
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Annu Rev Neurosci
2006[]; 29
(?): 229-57
PMID16776585
show ga
Deep brain stimulation (DBS) has provided remarkable benefits for people with a
variety of neurologic conditions. Stimulation of the ventral intermediate nucleus
of the thalamus can dramatically relieve tremor associated with essential tremor
or Parkinson disease (PD). Similarly, stimulation of the subthalamic nucleus or
the internal segment of the globus pallidus can substantially reduce
bradykinesia, rigidity, tremor, and gait difficulties in people with PD. Multiple
groups are attempting to extend this mode of treatment to other conditions. Yet,
the precise mechanism of action of DBS remains uncertain. Such studies have
importance that extends beyond clinical therapeutics. Investigations of the
mechanisms of action of DBS have the potential to clarify fundamental issues such
as the functional anatomy of selected brain circuits and the relationship between
activity in those circuits and behavior. Although we review relevant clinical
issues, we emphasize the importance of current and future investigations on these
topics.
free
free
free
