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2011 ; 34
(ä): 289-307
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Deep brain stimulation for psychiatric disorders
#MMPMID21692660
Holtzheimer PE
; Mayberg HS
Annu Rev Neurosci
2011[]; 34
(ä): 289-307
PMID21692660
show ga
Medications, psychotherapy, and other treatments are effective for many patients
with psychiatric disorders. However, with currently available interventions, a
substantial number of patients experience incomplete resolution of symptoms, and
relapse rates are high. In the search for better treatments, increasing interest
has focused on focal neuromodulation. This focus has been driven by improved
neuroanatomical models of mood, thought, and behavior regulation, as well as by
more advanced strategies for directly and focally altering neural activity. Deep
brain stimulation (DBS) is one of the most invasive focal neuromodulation
techniques available; data have supported its safety and efficacy in a number of
movement disorders. Investigators have produced preliminary data on the safety
and efficacy of DBS for several psychiatric disorders, as well. In this review,
we describe the development and justification for testing DBS for various
psychiatric disorders, carefully consider the available clinical data, and
briefly discuss potential mechanisms of action.