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10.1016/j.ygeno.2015.06.005 http://scihub22266oqcxt.onion/10.1016/j.ygeno.2015.06.005 C4540663!4540663 !26072433     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26072433 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genomics 2015 ; 106 (3 ): 159-164 Nephropedia Template TP {{tp|p=26072433 |t=2015. Decoding enhancers using massively parallel reporter assays |pdf=|usr=}}{{26072433 }} gab.com Text Decoding enhancers using massively parallel reporter assays JO: Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26072433 #FOAvip Enhancers control the timing, location and expression levels of their target genes. Nucleotide variation in enhancers has been shown to lead to numerous phenotypes, including human disease. While putative enhancer sequences and nucleotide variation within them can now be detected in a rapid manner using various genomic technologies, the understanding of the functional consequences of these variants still remains largely unknown. Massively parallel reporter assays (MPRAs) can overcome this hurdle by providing the ability to test thousands of sequences and nucleotide variants within them for enhancer activity en masse. Here, we describe this technology and specifically focus on how it is being used to obtain an increased understanding of enhancer regulatory code and grammar. Twit Text FOAVip Decoding enhancers using massively parallel reporter assays ????Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26072433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26072433 #FOAvip English Wikipedia <ref>{{Cite pmid|26072433 }}</ref> Decoding enhancers using massively parallel reporter assays #MMPMID26072433 Inoue F ; Ahituv N Genomics 2015[Sep]; 106 (3 ): 159-164 PMID26072433 show ga Enhancers control the timing, location and expression levels of their target genes. Nucleotide variation in enhancers has been shown to lead to numerous phenotypes, including human disease. While putative enhancer sequences and nucleotide variation within them can now be detected in a rapid manner using various genomic technologies, the understanding of the functional consequences of these variants still remains largely unknown. Massively parallel reporter assays (MPRAs) can overcome this hurdle by providing the ability to test thousands of sequences and nucleotide variants within them for enhancer activity en masse. Here, we describe this technology and specifically focus on how it is being used to obtain an increased understanding of enhancer regulatory code and grammar. |*Enhancer Elements, Genetic [MESH] |Binding Sites/genetics [MESH] |Gene Expression Regulation [MESH] |Genomics [MESH] |High-Throughput Nucleotide Sequencing/*methods [MESH] |Humans [MESH] |Promoter Regions, Genetic [MESH] |Sequence Analysis, DNA/*methods [MESH]Decoding enhancers using massively parallel reporter assays (epmc).pdf DeepDyve Pubget Overpricing