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2017 ; 34
(5
): 472-477
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Decoding chemical communication in nematodes
#MMPMID28386618
Butcher RA
Nat Prod Rep
2017[May]; 34
(5
): 472-477
PMID28386618
show ga
The nematode Caenorhabditis elegans produces tens, if not hundreds, of different
ascarosides as pheromones to communicate with other members of its species.
Overlapping mixtures of these pheromones affect the development of the worm and a
variety of different behaviors. The ascarosides represent a unique tool for
dissecting the neural circuitry that controls behavior and that connects to
important signaling pathways, such as the insulin and TGF? pathways, that lie at
the nexus of development, metabolism, and lifespan in C. elegans. However, the
exact physiological roles of many of the ascarosides are unclear, especially
since many of these pheromones likely have multiple functions depending on their
concentrations, the presence of other pheromones, and a variety of other factors.
Determining these physiological roles will be facilitated by top-down approaches
to characterize the pheromone receptors and their function, as well as bottom-up
approaches to characterize the pheromone biosynthetic enzymes and their
regulation.
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