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10.5483/bmbrep.2017.50.10.147 http://scihub22266oqcxt.onion/10.5483/bmbrep.2017.50.10.147 C5683818!5683818 !28768566     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28768566 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMB+Rep 2017 ; 50 (10 ): 496-503 Nephropedia Template TP {{tp|p=28768566 |t=2017. Dead cell phagocytosis and innate immune checkpoint |pdf=|usr=}}{{28768566 }} gab.com Text Dead cell phagocytosis and innate immune checkpoint JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=28768566 #FOAvip The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations. [BMB Reports 2017; 50(10): 496-503]. Twit Text FOAVip Dead cell phagocytosis and innate immune checkpoint ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=28768566 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28768566 #FOAvip English Wikipedia <ref>{{Cite pmid|28768566 }}</ref> Dead cell phagocytosis and innate immune checkpoint #MMPMID28768566 Yoon KW BMB Rep 2017[Oct]; 50 (10 ): 496-503 PMID28768566 show ga The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations. [BMB Reports 2017; 50(10): 496-503]. |Animals [MESH] |Apoptosis/immunology [MESH] |Cell Death [MESH] |Cytophagocytosis/*immunology/*physiology [MESH] |Humans [MESH] |Immune Tolerance [MESH] |Immunity, Innate/*immunology [MESH] |Phagocytes/physiology [MESH]Dead cell phagocytosis and innate immune checkpoint (epmc).pdf DeepDyve Pubget Overpricing