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10.1016/j.tcb.2014.07.008 http://scihub22266oqcxt.onion/10.1016/j.tcb.2014.07.008 C4252702!4252702 !25150593     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25150593 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Cell+Biol 2014 ; 24 (12 ): 734-42 Nephropedia Template TP {{tp|p=25150593 |t=2014. Damage control: cellular mechanisms of plasma membrane repair |pdf=|usr=}}{{25150593 }} gab.com Text Damage control: cellular mechanisms of plasma membrane repair JO: Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25150593 #FOAvip When wounded, eukaryotic cells reseal in a few seconds. Ca(2+) influx induces exocytosis of lysosomes, a process previously thought to promote repair by 'patching' wounds. New evidence suggests that resealing involves direct wound removal. Exocytosis of lysosomal acid sphingomyelinase (ASM) triggers endocytosis of lesions followed by intracellular degradation. Characterization of injury-induced endosomes revealed a role for caveolae, sphingolipid-enriched plasma membrane invaginations that internalize toxin pores and are abundant in mechanically stressed cells. These findings provide a novel mechanistic explanation for the muscle pathology associated with mutations in caveolar proteins. Membrane remodeling by the ESCRT complex was also recently shown to participate in small-wound repair, emphasizing that cell resealing involves previously unrecognized mechanisms for lesion removal that are distinct from the patch model. Twit Text FOAVip Damage control: cellular mechanisms of plasma membrane repair ????Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25150593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25150593 #FOAvip English Wikipedia <ref>{{Cite pmid|25150593 }}</ref> Damage control: cellular mechanisms of plasma membrane repair #MMPMID25150593 Andrews NW ; Almeida PE ; Corrotte M Trends Cell Biol 2014[Dec]; 24 (12 ): 734-42 PMID25150593 show ga When wounded, eukaryotic cells reseal in a few seconds. Ca(2+) influx induces exocytosis of lysosomes, a process previously thought to promote repair by 'patching' wounds. New evidence suggests that resealing involves direct wound removal. Exocytosis of lysosomal acid sphingomyelinase (ASM) triggers endocytosis of lesions followed by intracellular degradation. Characterization of injury-induced endosomes revealed a role for caveolae, sphingolipid-enriched plasma membrane invaginations that internalize toxin pores and are abundant in mechanically stressed cells. These findings provide a novel mechanistic explanation for the muscle pathology associated with mutations in caveolar proteins. Membrane remodeling by the ESCRT complex was also recently shown to participate in small-wound repair, emphasizing that cell resealing involves previously unrecognized mechanisms for lesion removal that are distinct from the patch model. |Calcium Signaling/genetics [MESH] |Caveolae/*metabolism [MESH] |Cell Membrane/genetics/*metabolism [MESH] |Endosomal Sorting Complexes Required for Transport/genetics [MESH] |Eukaryota/genetics/metabolism [MESH] |Exocytosis/genetics [MESH] |Lysosomes/genetics/metabolism [MESH] |Sphingomyelin Phosphodiesterase/genetics/metabolism [MESH]Damage control: cellular mechanisms of plasma membrane repair (epmc).pdf DeepDyve Pubget Overpricing