DUBA-UBR5 axis: other than transactivation
#MMPMID25633593
Wu C
; Chen Z
; Kuchroo VK
Cell Res
2015[Mar]; 25
(3
): 273-4
PMID25633593
show ga
The genomic and transcriptomic analysis has led to the identification of
transcriptional networks that affect the differentiation of Th17 cells, while the
protein-protein networks and the posttranslational modifications that control the
development of Th17 cells have not been established yet. A recent publication by
Rutz et al. in Nature describes a novel deubiquitylating enzyme DUBA as a
negative regulator for IL-17 by regulating stability of ROR?t, the master
transcription factor that induces Th17 cells.
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