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2016 ; 6
(ä): 24482
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DRAMP: a comprehensive data repository of antimicrobial peptides
#MMPMID27075512
Fan L
; Sun J
; Zhou M
; Zhou J
; Lao X
; Zheng H
; Xu H
Sci Rep
2016[Apr]; 6
(ä): 24482
PMID27075512
show ga
The growing problem of antibiotic-resistant microorganisms results in an urgent
need for substitutes to conventional antibiotics with novel modes of action and
effective activities. Antimicrobial peptides (AMPs), produced by a wide variety
of living organisms acting as a defense mechanism against invading pathogenic
microbes, are considered to be such promising alternatives. AMPs display a broad
spectrum of antimicrobial activity and a low propensity for developing
resistance. Therefore, a thorough understanding of AMPs is essential to exploit
them as antimicrobial drugs. Considering this, we developed a comprehensive
user-friendly data repository of antimicrobial peptides (DRAMP), which holds
17349 antimicrobial sequences, including 4571 general AMPs, 12704 patented
sequences and 74 peptides in drug development. Entries in the database have
detailed annotations, especially detailed antimicrobial activity data (shown as
target organism with MIC value) and structure information. Annotations also
include accession numbers crosslinking to Pubmed, Swiss-prot and Protein Data
Bank (PDB). The website of the database comes with easy-to-operate browsing as
well as searching with sorting and filtering functionalities. Several useful
sequence analysis tools are provided, including similarity search, sequence
alignment and conserved domain search (CD-Search). DRAMP should be a useful
resource for the development of novel antimicrobial peptide drugs.