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10.1186/s13059-016-1055-4

http://scihub22266oqcxt.onion/10.1186/s13059-016-1055-4
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suck abstract from ncbi


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pmid27640875
      Genome+Biol 2016 ; 17 (1 ): 187
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  • DNA-guided genome editing using structure-guided endonucleases #MMPMID27640875
  • Varshney GK ; Burgess SM
  • Genome Biol 2016[Sep]; 17 (1 ): 187 PMID27640875 show ga
  • The search for novel ways to target and alter the genomes of living organisms accelerated rapidly this decade with the discovery of CRISPR/Cas9. Since the initial discovery, efforts to find alternative methods for altering the genome have expanded. A new study presenting an alternative approach has been demonstrated that utilizes flap endonuclease 1 (FEN-1) fused to the Fok1 endonuclease, which shows potential for DNA-guided genome targeting in vivo.
  • |*Gene Editing [MESH]
  • |*Genome [MESH]
  • |Animals [MESH]
  • |CRISPR-Cas Systems [MESH]
  • |DNA/chemistry/genetics/metabolism [MESH]
  • |Endonucleases/chemistry/genetics/*metabolism [MESH]


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