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2020 ; 65
(ä): 21-27
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DNA vaccines: prime time is now
#MMPMID32259744
Gary EN
; Weiner DB
Curr Opin Immunol
2020[Aug]; 65
(ä): 21-27
PMID32259744
show ga
Recently newer synthetic DNA vaccines have been rapidly advanced to clinical
study and have demonstrated an impressive degree of immune potency and
tolerability. Improvements in DNA delivery over prior needle and syringe
approaches include jet delivery, gene gun delivery, among others. Among the most
effective of these new delivery methods, advanced electroporation (EP), combined
with other advances, induces robust humoral and cellular immunity in both
preventative as well as therapeutic studies. Advancements in the design of the
DNA inserts include leader sequence changes, RNA and codon optimizations,
improved insert designs, increased concentrations of DNA, and skin delivery,
appear to complement newer delivery strategies. These advances also provide a
framework for the in vivo production of synthetic DNA biologics. In this review,
we focus on recent studies of synthetic DNA vaccines in the clinic for the
prevention or treatment of infectious diseases with a focus on adaptive
electroporation for delivery, and briefly summarize novel preclinical data
advancing the in vivo delivery of DNA-encoded antibody-like biologics.
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