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2016 ; 8
(Suppl 1
): 75-87
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English Wikipedia
DNA supercoiling during transcription
#MMPMID28275417
Ma J
; Wang MD
Biophys Rev
2016[Nov]; 8
(Suppl 1
): 75-87
PMID28275417
show ga
The twin-supercoiled-domain model describes how transcription can drive DNA
supercoiling, and how DNA supercoiling, in turn plays an important role in
regulating gene transcription. In vivo and in vitro experiments have disclosed
many details of the complex interactions in this relationship, and recently new
insights have been gained with the help of genome-wide DNA supercoiling mapping
techniques and single molecule methods. This review summarizes the general
mechanisms of the interplay between DNA supercoiling and transcription, considers
the biological implications, and focuses on recent important discoveries and
technical advances in this field. We highlight the significant impact of DNA
supercoiling in transcription, but also more broadly in all processes operating
on DNA.