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2010 ; 1
(3
): 227-36
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DNA replication licensing control and rereplication prevention
#MMPMID21203969
Li C
; Jin J
Protein Cell
2010[Mar]; 1
(3
): 227-36
PMID21203969
show ga
Eukaryotic DNA replication is tightly restricted to only once per cell cycle in
order to maintain genome stability. Cells use multiple mechanisms to control the
assembly of the prereplication complex (pre-RC), a process known as replication
licensing. This review focuses on the regulation of replication licensing by
posttranslational modifications of the licensing factors, including
phosphorylation, ubiquitylation and acetylation. These modifications are critical
in establishing the pre-RC complexes as well as preventing rereplication in each
cell cycle. The relationship between rereplication and diseases, including cancer
and virus infection, is discussed as well.