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2016 ; 44
(9
): 783-790
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DNA methylation in hematopoietic development and disease
#MMPMID27178734
Gore AV
; Weinstein BM
Exp Hematol
2016[Sep]; 44
(9
): 783-790
PMID27178734
show ga
DNA methylation is an important epigenetic modification that can have profound
and widespread effects on gene expression and on cellular fate and function.
Recent work has indicated that DNA methylation plays a critical role in
hematopoietic development and hematopoietic disease. DNA methyltransferases and
Ten-eleven translocation enzymes are required to add and remove methyl "marks"
from DNA, respectively, and both sets of genes have been found necessary for
proper formation and maintenance of hematopoietic stem cells and for
differentiation of downstream hematopoietic lineages during development. DNA
methylation and demethylation enzymes have also been implicated in hematopoietic
disorders such as acute myeloid leukemia and myelodysplastic syndrome. Here, we
review some of the recent literature regarding the role of DNA methylation in
hematopoietic health and disease.