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10.1016/j.exphem.2016.04.013

http://scihub22266oqcxt.onion/10.1016/j.exphem.2016.04.013
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suck abstract from ncbi


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pmid27178734
      Exp+Hematol 2016 ; 44 (9 ): 783-790
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  • DNA methylation in hematopoietic development and disease #MMPMID27178734
  • Gore AV ; Weinstein BM
  • Exp Hematol 2016[Sep]; 44 (9 ): 783-790 PMID27178734 show ga
  • DNA methylation is an important epigenetic modification that can have profound and widespread effects on gene expression and on cellular fate and function. Recent work has indicated that DNA methylation plays a critical role in hematopoietic development and hematopoietic disease. DNA methyltransferases and Ten-eleven translocation enzymes are required to add and remove methyl "marks" from DNA, respectively, and both sets of genes have been found necessary for proper formation and maintenance of hematopoietic stem cells and for differentiation of downstream hematopoietic lineages during development. DNA methylation and demethylation enzymes have also been implicated in hematopoietic disorders such as acute myeloid leukemia and myelodysplastic syndrome. Here, we review some of the recent literature regarding the role of DNA methylation in hematopoietic health and disease.
  • |*DNA Methylation [MESH]
  • |*Epigenesis, Genetic [MESH]
  • |*Gene Expression Regulation [MESH]
  • |Animals [MESH]
  • |Cell Differentiation/genetics [MESH]
  • |Genetic Predisposition to Disease [MESH]
  • |Hematologic Diseases/*genetics/metabolism [MESH]
  • |Hematologic Neoplasms/genetics/metabolism/pathology [MESH]
  • |Hematopoiesis/*genetics [MESH]
  • |Hematopoietic Stem Cells/cytology/metabolism [MESH]


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