Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms13337 http://scihub22266oqcxt.onion/10.1038/ncomms13337 C5097161!5097161 !27808093     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27808093 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 13337 Nephropedia Template TP {{tp|p=27808093 |t=2016. DNA looping mediates nucleosome transfer |pdf=|usr=}}{{27808093 }} gab.com Text DNA looping mediates nucleosome transfer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27808093 #FOAvip Proper cell function requires preservation of the spatial organization of chromatin modifications. Maintenance of this epigenetic landscape necessitates the transfer of parental nucleosomes to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replication fork dynamics. This creates a formidable setting from which to isolate the central mechanism of transfer. Here we utilized a minimal experimental system to track the fate of a single nucleosome following its displacement, and examined whether DNA mechanics itself, in the absence of any chaperones or assembly factors, may serve as a platform for the transfer process. We found that the nucleosome is passively transferred to available dsDNA as predicted by a simple physical model of DNA loop formation. These results demonstrate a fundamental role for DNA mechanics in mediating nucleosome transfer and preserving epigenetic integrity during replication. Twit Text FOAVip DNA looping mediates nucleosome transfer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27808093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27808093 #FOAvip English Wikipedia <ref>{{Cite pmid|27808093 }}</ref> DNA looping mediates nucleosome transfer #MMPMID27808093 Brennan LD ; Forties RA ; Patel SS ; Wang MD Nat Commun 2016[Nov]; 7 (ä): 13337 PMID27808093 show ga Proper cell function requires preservation of the spatial organization of chromatin modifications. Maintenance of this epigenetic landscape necessitates the transfer of parental nucleosomes to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replication fork dynamics. This creates a formidable setting from which to isolate the central mechanism of transfer. Here we utilized a minimal experimental system to track the fate of a single nucleosome following its displacement, and examined whether DNA mechanics itself, in the absence of any chaperones or assembly factors, may serve as a platform for the transfer process. We found that the nucleosome is passively transferred to available dsDNA as predicted by a simple physical model of DNA loop formation. These results demonstrate a fundamental role for DNA mechanics in mediating nucleosome transfer and preserving epigenetic integrity during replication. |DNA Replication/*physiology [MESH] |DNA/*genetics/metabolism [MESH] |Epigenesis, Genetic/*physiology [MESH] |HeLa Cells [MESH] |Histone Chaperones/physiology [MESH] |Humans [MESH]DNA looping mediates nucleosome transfer (epmc).pdf DeepDyve Pubget Overpricing