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10.1016/j.tcb.2016.04.012

http://scihub22266oqcxt.onion/10.1016/j.tcb.2016.04.012
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suck abstract from ncbi


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pmid27262731
      Trends+Cell+Biol 2016 ; 26 (9 ): 640-654
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  • DNA Polymerases Divide the Labor of Genome Replication #MMPMID27262731
  • Lujan SA ; Williams JS ; Kunkel TA
  • Trends Cell Biol 2016[Sep]; 26 (9 ): 640-654 PMID27262731 show ga
  • DNA polymerases synthesize DNA in only one direction, but large genomes require RNA priming and bidirectional replication from internal origins. We review here the physical, chemical, and evolutionary constraints underlying these requirements. We then consider the roles of the major eukaryotic replicases, DNA polymerases ?, ?, and ?, in replicating the nuclear genome. Pol ? has long been known to extend RNA primers at origins and on Okazaki fragments that give rise to the nascent lagging strand. Taken together, more recent results of mutation and ribonucleotide incorporation mapping, electron microscopy, and immunoprecipitation of nascent DNA now lead to a model wherein Pol ? and Pol ?, respectively, synthesize the majority of the nascent leading and lagging strands of undamaged DNA.
  • |*DNA Replication [MESH]
  • |*Genome [MESH]
  • |Animals [MESH]
  • |DNA-Directed DNA Polymerase/*metabolism [MESH]
  • |Eukaryotic Cells/metabolism [MESH]
  • |Humans [MESH]
  • |Models, Biological [MESH]


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