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2016 ; 6
(5
): 710-25
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DNA Nanotechnology for Cancer Therapy
#MMPMID27022418
Kumar V
; Palazzolo S
; Bayda S
; Corona G
; Toffoli G
; Rizzolio F
Theranostics
2016[]; 6
(5
): 710-25
PMID27022418
show ga
DNA nanotechnology is an emerging and exciting field, and represents a forefront
frontier for the biomedical field. The specificity of the interactions between
complementary base pairs makes DNA an incredible building material for
programmable and very versatile two- and three-dimensional nanostructures called
DNA origami. Here, we analyze the DNA origami and DNA-based nanostructures as a
drug delivery system. Besides their physical-chemical nature, we dissect the
critical factors such as stability, loading capability, release and
immunocompatibility, which mainly limit in vivo applications. Special attention
was dedicated to highlighting the boundaries to be overcome to bring DNA
nanostructures closer to the bedside of patients.