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10.1074/mcp.M114.046904 http://scihub22266oqcxt.onion/10.1074/mcp.M114.046904 C4563731!4563731 !26091700     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26091700 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Proteomics 2015 ; 14 (9 ): 2493-509 Nephropedia Template TP {{tp|p=26091700 |t=2015. Cytoskeletal Components Define Protein Location to Membrane Microdomains |pdf=|usr=}}{{26091700 }} gab.com Text Cytoskeletal Components Define Protein Location to Membrane Microdomains JO: Mol Cell Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=26091700 #FOAvip The plasma membrane is an important compartment that undergoes dynamic changes in composition upon external or internal stimuli. The dynamic subcompartmentation of proteins in ordered low-density (DRM) and disordered high-density (DSM) membrane phases is hypothesized to require interactions with cytoskeletal components. Here, we systematically analyzed the effects of actin or tubulin disruption on the distribution of proteins between membrane density phases. We used a proteomic screen to identify candidate proteins with altered submembrane location, followed by biochemical or cell biological characterization in Arabidopsis thaliana. We found that several proteins, such as plasma membrane ATPases, receptor kinases, or remorins resulted in a differential distribution between membrane density phases upon cytoskeletal disruption. Moreover, in most cases, contrasting effects were observed: Disruption of actin filaments largely led to a redistribution of proteins from DRM to DSM membrane fractions while disruption of tubulins resulted in general depletion of proteins from the membranes. We conclude that actin filaments are necessary for dynamic movement of proteins between different membrane phases and that microtubules are not necessarily important for formation of microdomains as such, but rather they may control the protein amount present in the membrane phases. Twit Text FOAVip Cytoskeletal Components Define Protein Location to Membrane Microdomains ????Mol Cell Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=26091700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26091700 #FOAvip English Wikipedia <ref>{{Cite pmid|26091700 }}</ref> Cytoskeletal Components Define Protein Location to Membrane Microdomains #MMPMID26091700 Szymanski WG ; Zauber H ; Erban A ; Gorka M ; Wu XN ; Schulze WX Mol Cell Proteomics 2015[Sep]; 14 (9 ): 2493-509 PMID26091700 show ga The plasma membrane is an important compartment that undergoes dynamic changes in composition upon external or internal stimuli. The dynamic subcompartmentation of proteins in ordered low-density (DRM) and disordered high-density (DSM) membrane phases is hypothesized to require interactions with cytoskeletal components. Here, we systematically analyzed the effects of actin or tubulin disruption on the distribution of proteins between membrane density phases. We used a proteomic screen to identify candidate proteins with altered submembrane location, followed by biochemical or cell biological characterization in Arabidopsis thaliana. We found that several proteins, such as plasma membrane ATPases, receptor kinases, or remorins resulted in a differential distribution between membrane density phases upon cytoskeletal disruption. Moreover, in most cases, contrasting effects were observed: Disruption of actin filaments largely led to a redistribution of proteins from DRM to DSM membrane fractions while disruption of tubulins resulted in general depletion of proteins from the membranes. We conclude that actin filaments are necessary for dynamic movement of proteins between different membrane phases and that microtubules are not necessarily important for formation of microdomains as such, but rather they may control the protein amount present in the membrane phases. |Actins/*metabolism [MESH] |Arabidopsis Proteins/*metabolism [MESH] |Arabidopsis/*cytology/*metabolism [MESH] |Cell Culture Techniques [MESH] |Cell Membrane/metabolism [MESH] |Proteomics/methods [MESH]Cytoskeletal Components Define Protein Location to Membrane Microdomai(epmc).pdf DeepDyve Pubget Overpricing