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10.4110/in.2015.15.4.186

http://scihub22266oqcxt.onion/10.4110/in.2015.15.4.186
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C4553256!4553256 !26330804
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suck abstract from ncbi


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pmid26330804
      Immune+Netw 2015 ; 15 (4 ): 186-90
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  • Cytomegalovirus Infection and Memory T Cell Inflation #MMPMID26330804
  • Kim J ; Kim AR ; Shin EC
  • Immune Netw 2015[Aug]; 15 (4 ): 186-90 PMID26330804 show ga
  • Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8(+) T cells, termed 'memory inflation'. The expanded CMV-specific CD8(+) T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8(+) T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.
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