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2015 ; 15
(4
): 186-90
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Cytomegalovirus Infection and Memory T Cell Inflation
#MMPMID26330804
Kim J
; Kim AR
; Shin EC
Immune Netw
2015[Aug]; 15
(4
): 186-90
PMID26330804
show ga
Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic
and results in latent infection. CMV reactivation occasionally occurs in healthy
individuals according to their immune status over time. T cell responses to CMV
are restricted to a limited number of immunodominant epitopes, as compared to
responses to other chronic or persistent viruses. This response results in
progressive, prolonged expansion of CMV-specific CD8(+) T cells, termed 'memory
inflation'. The expanded CMV-specific CD8(+) T cell population is extraordinarily
large and is more prominent in the elderly. CMV-specific CD8(+) T cells possess
rather similar phenotypic and functional features to those of replicative
senescent T cells. In this review, we discuss the general features of
CMV-specific inflationary memory T cells and the factors involved in memory
inflation.