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2016 ; 53
(ä): 39-44
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Semin Cell Dev Biol
2016[May]; 53
(ä): 39-44
PMID26481973
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Cytokinesis, the final step of cell division, is a great example of robust cell
shape regulation. A wide variety of cells ranging from the unicellular
Dictyostelium to human cells in tissues proceed through highly similar,
stereotypical cell shape changes during cell division. Typically, cells first
round up forming a cleavage furrow in the middle, which constricts resulting in
the formation of two daughter cells. Tight control of cytokinesis is essential
for proper segregation of genetic and cellular materials, and its failure is
deleterious to cell viability. Thus, biological systems have developed elaborate
mechanisms to ensure high fidelity of cytokinesis, including the existence of
multiple biochemical and mechanical pathways regulated through feedback. In this
review, we focus on the built-in redundancy of the cytoskeletal machinery that
allows cells to divide successfully in a variety of biological and mechanical
contexts. Using Dictyostelium cytokinesis as an example, we demonstrate that the
crosstalk between biochemical and mechanical signaling through feedback ensures
correct assembly and function of the cell division machinery.
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