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2015 ; 7
(4
): a015834
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Cytokinesis in animal cells
#MMPMID25680833
D'Avino PP
; Giansanti MG
; Petronczki M
Cold Spring Harb Perspect Biol
2015[Feb]; 7
(4
): a015834
PMID25680833
show ga
Cell division ends with the physical separation of the two daughter cells, a
process known as cytokinesis. This final event ensures that nuclear and
cytoplasmic contents are accurately partitioned between the two nascent cells.
Cytokinesis is one of the most dramatic changes in cell shape and requires an
extensive reorganization of the cell's cytoskeleton. Here, we describe the
cytoskeletal structures, factors, and signaling pathways that orchestrate this
robust and yet highly dynamic process in animal cells. Finally, we discuss
possible future directions in this growing area of cell division research and its
implications in human diseases, including cancer.