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10.1155/2017/7586174 http://scihub22266oqcxt.onion/10.1155/2017/7586174 C5504949!5504949 !28740334     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28740334 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2017 ; 2017 (ä): 7586174 Nephropedia Template TP {{tp|p=28740334 |t=2017. Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |pdf=|usr=}}{{28740334 }} gab.com Text Cytokines in Endocrine Dysfunction of Plasma Cell Disorders JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28740334 #FOAvip Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. To understand the origin of the endocrine symptoms associated with MG, we overview here the current knowledge on the complexity of interactions between cytokines and the endocrine system in MG and discuss the perspectives for both the diagnosis and treatments for this class of diseases. We also illustrate the role of major cytokines and growth factors such as IL-6, IL-1?, TNF-?, and VEGF in the endocrine system, as these tumor-relevant signaling molecules not only help the clonal expansion and invasion of the tumor cells but also influence cellular metabolism through autocrine, paracrine, and endocrine mechanisms. We further discuss the broader impact of these tumor environment-derived molecules and proinflammatory state on systemic hormone signaling. The diagnostic challenges and clinical work-up are illustrated from the point of view of an endocrinologist. Twit Text FOAVip Cytokines in Endocrine Dysfunction of Plasma Cell Disorders ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28740334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28740334 #FOAvip English Wikipedia <ref>{{Cite pmid|28740334 }}</ref> Cytokines in Endocrine Dysfunction of Plasma Cell Disorders #MMPMID28740334 Feigerlová E ; Battaglia-Hsu SF Mediators Inflamm 2017[]; 2017 (ä): 7586174 PMID28740334 show ga Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. To understand the origin of the endocrine symptoms associated with MG, we overview here the current knowledge on the complexity of interactions between cytokines and the endocrine system in MG and discuss the perspectives for both the diagnosis and treatments for this class of diseases. We also illustrate the role of major cytokines and growth factors such as IL-6, IL-1?, TNF-?, and VEGF in the endocrine system, as these tumor-relevant signaling molecules not only help the clonal expansion and invasion of the tumor cells but also influence cellular metabolism through autocrine, paracrine, and endocrine mechanisms. We further discuss the broader impact of these tumor environment-derived molecules and proinflammatory state on systemic hormone signaling. The diagnostic challenges and clinical work-up are illustrated from the point of view of an endocrinologist. |Animals [MESH] |Cytokines/*metabolism [MESH] |Endocrine System/*metabolism/*pathology [MESH] |Humans [MESH] |Interleukin-1beta/metabolism [MESH] |Interleukin-6/metabolism [MESH] |Neoplasms, Plasma Cell [MESH] |Plasma Cells/*metabolism/*pathology [MESH] |Tumor Necrosis Factor-alpha/metabolism [MESH]Cytokines in Endocrine Dysfunction of Plasma Cell Disorders (epmc).pdf DeepDyve Pubget Overpricing