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2014 ; 15
(6
): 122
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Cyclin-dependent kinases
#MMPMID25180339
Malumbres M
Genome Biol
2014[]; 15
(6
): 122
PMID25180339
show ga
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a
separate subunit - a cyclin - that provides domains essential for enzymatic
activity. CDKs play important roles in the control of cell division and modulate
transcription in response to several extra- and intracellular cues. The
evolutionary expansion of the CDK family in mammals led to the division of CDKs
into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five
transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the
prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few
cyclins, consistent with functional specialization during evolution. This review
summarizes how, although CDKs are traditionally separated into cell-cycle or
transcriptional CDKs, these activities are frequently combined in many family
members. Not surprisingly, deregulation of this family of proteins is a hallmark
of several diseases, including cancer, and drug-targeted inhibition of specific
members has generated very encouraging results in clinical trials.
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