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2016 ; 40
(5
): 753-73
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Cyclic diguanylate signaling in Gram-positive bacteria
#MMPMID27354347
Purcell EB
; Tamayo R
FEMS Microbiol Rev
2016[Sep]; 40
(5
): 753-73
PMID27354347
show ga
The nucleotide second messenger 3'-5' cyclic diguanylate monophosphate (c-di-GMP)
is a central regulator of the transition between motile and non-motile lifestyles
in bacteria, favoring sessility. Most research investigating the functions of
c-di-GMP has focused on Gram-negative species, especially pathogens. Recent work
in Gram-positive species has revealed that c-di-GMP plays similar roles in
Gram-positives, though the precise targets and mechanisms of regulation may
differ. The majority of bacterial life exists in a surface-associated state, with
motility allowing bacteria to disseminate and colonize new environments. c-di-GMP
signaling regulates flagellum biosynthesis and production of adherence factors
and appears to be a primary mechanism by which bacteria sense and respond to
surfaces. Ultimately, c-di-GMP influences the ability of a bacterium to alter its
transcriptional program, physiology and behavior upon surface contact. This
review discusses how bacteria are able to sense a surface via flagella and type
IV pili, and the role of c-di-GMP in regulating the response to surfaces, with
emphasis on studies of Gram-positive bacteria.
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