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2013 ; 27
(3
): 391-404
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Cutaneous lupus erythematosus: diagnosis and treatment
#MMPMID24238695
Okon LG
; Werth VP
Best Pract Res Clin Rheumatol
2013[Jun]; 27
(3
): 391-404
PMID24238695
show ga
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic
manifestations, which may or may not be associated with the development of
systemic disease. Cutaneous lupus is divided into several sub-types, including
acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes
discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus
and lupus tumidus. The diagnosis of these diseases requires proper classification
of the sub-type, through a combination of physical examination, laboratory
studies, histology, antibody serology and occasionally direct immunofluorescence,
while ensuring to exclude systemic disease. The treatment of cutaneous lupus
consists of patient education on proper sun protection along with appropriate
topical and systemic agents. Systemic agents are indicated in cases of
widespread, scarring or treatment-refractory disease. In this chapter, we discuss
issues in classification and diagnosis of the various sub-types of CLE, as well
as provide an update on therapeutic management.