Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24296353
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cold+Spring+Harb+Perspect+Med
2013 ; 3
(12
): a017772
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cutaneous Notch signaling in health and disease
#MMPMID24296353
Nowell C
; Radtke F
Cold Spring Harb Perspect Med
2013[Dec]; 3
(12
): a017772
PMID24296353
show ga
The development and maintenance of the skin are dependent on myriad signaling
pathways that regulate a variety of cellular processes. In cutaneous epithelial
cells, the Notch cascade plays a central role in ensuring that proliferation and
differentiation are coordinated appropriately, a function that it imparts during
both ontogeny and homeostasis. Aberrations of the Notch signaling pathway result
in severe abnormalities in the epidermis and its appendages and cause functional
defects such as perturbed barrier function. In addition, impaired Notch signaling
is associated with diseases of the skin such as atopy and cancer. The pathology
associated with aberrant cutaneous Notch signaling reflects the complex
mechanisms underpinning its function in this tissue and involves both
cell-autonomous and nonautonomous mechanisms. This review summarizes our current
knowledge of the role of Notch signaling in the skin during health and disease.