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2017 ; 36
(9
): 1120-1122
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Cut in translation: ribosome-dependent mRNA decay
#MMPMID28396493
Lalaouna D
; Massé E
EMBO J
2017[May]; 36
(9
): 1120-1122
PMID28396493
show ga
Transcription and translation are two complex mechanisms that are tightly coupled
in prokaryotic cells. Even before the completion of transcription, ribosomes
attach to the nascent mRNA and initiate protein synthesis. Remarkably, recent
publications have indicated an association between translation and decay of
certain mRNAs. In this issue of The EMBO Journal, Leroy et al (2017) depicts a
fascinating mechanism of mRNA degradation, which involves the ribosome-associated
ribonuclease Rae1 in Bacillus subtilis In a translation-dependent manner, Rae1
binds the ribosomal aminoacylation (A)-site and cleaves between specific codons
of the targeted mRNA.