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10.4103/1673-5374.200794 http://scihub22266oqcxt.onion/10.4103/1673-5374.200794 C5361492!5361492 !28400790     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28400790 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neural+Regen+Res 2017 ; 12 (2 ): 181-184 Nephropedia Template TP {{tp|p=28400790 |t=2017. Current view and perspectives in amyotrophic lateral sclerosis |pdf=|usr=}}{{28400790 }} gab.com Text Current view and perspectives in amyotrophic lateral sclerosis JO: Neural Regen Res http://www.kidney.de/pget.php?&tw=1&pmid=28400790 #FOAvip Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole (the only disease-modifying drug approved for this disease). Nowadays, there is still no curative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientific knowledge in the field of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent advances and promising therapeutics and biomarkers in the field of ALS. Twit Text FOAVip Current view and perspectives in amyotrophic lateral sclerosis ????Neural Regen Res http://www.kidney.de/pget.php?&tw=1&pmid=28400790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28400790 #FOAvip English Wikipedia <ref>{{Cite pmid|28400790 }}</ref> Current view and perspectives in amyotrophic lateral sclerosis #MMPMID28400790 Mathis S ; Couratier P ; Julian A ; Corcia P ; Le Masson G Neural Regen Res 2017[Feb]; 12 (2 ): 181-184 PMID28400790 show ga Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole (the only disease-modifying drug approved for this disease). Nowadays, there is still no curative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientific knowledge in the field of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent advances and promising therapeutics and biomarkers in the field of ALS. äCurrent view and perspectives in amyotrophic lateral sclerosis (epmc).pdf DeepDyve Pubget Overpricing