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2015 ; 6
(7-8
): 288-302
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Current understanding of mdig/MINA in human cancers
#MMPMID26413213
Thakur C
; Chen F
Genes Cancer
2015[Jul]; 6
(7-8
): 288-302
PMID26413213
show ga
Mineral dust-induced gene, mdig has recently been identified and is known to be
overexpressed in a majority of human cancers and holds predictive power in the
poor prognosis of the disease. Mdig is an environmentally expressed gene that is
involved in cell proliferation, neoplastic transformation and immune regulation.
With the advancement in deciphering the prognostic role of mdig in human cancers,
our understanding on how mdig renders a normal cell to undergo malignant
transformation is still very limited. This article reviews the current knowledge
of the mdig gene in context to human neoplasias and its relation to the
clinico-pathologic factors predicting the outcome of the disease in patients. It
also emphasizes on the promising role of mdig that can serve as a potential
candidate for biomarker discovery and as a therapeutic target in inflammation and
cancers. Considering the recent advances in understanding the underlying
mechanisms of tumor formation, more preclinical and clinical research is required
to validate the potential of using mdig as a novel biological target of
therapeutic and diagnostic value. SUMMARY: Expression level of mdig influences
the prognosis of several human cancers especially cancers of the breast and lung.
Evaluation of mdig in cancers can offer novel biomarker with potential
therapeutic interventions for the early assessment of cancer development in
patients.
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