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2011 ; 2
(8
): 604-11
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Current understanding of Th2 cell differentiation and function
#MMPMID21904976
Li Z
; Zhang Y
; Sun B
Protein Cell
2011[Aug]; 2
(8
): 604-11
PMID21904976
show ga
Helper T cell (Th) has been identified as a critical immune cell for regulating
immune response since 1980s. The type 2 helper Tcell (Th2), characterized by the
production of interleukin-4 (IL-4), IL-5 and IL-13, plays a critical role in
immune response against helminths invading cutaneous or mucosal sites. It also
has a functional role in the pathophysiology of allergic diseases such as asthma
and allergic diarrhea. Currently, most studies have shed light on Th2 cell
function and behavior in specific diseases, such as asthma and helminthes
inflammation, but not on Th2 cell itself and its differentiation. Based on
different cytokines and specific behavior in recent research, Th2 cell is also
regarded as new subtypes of T cell, such as IL-9 secreting T cell (Th9) and
CXCR5(+) T follicular helper cells. Here, we will discuss the latest view of Th2
cell towards their function and the involvement of Th2 cell in diseases.
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