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2014 ; 2
(2
): 53-60
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Current status of vascularized composite tissue allotransplantation
#MMPMID27602363
Edtinger K
; Yang X
; Uehara H
; Tullius SG
Burns Trauma
2014[]; 2
(2
): 53-60
PMID27602363
show ga
Vascularized composite tissue allotransplantation (VCA) offers treatment options
of complex functional deficiencies that cannot be repaired with conventional
reconstructive methods. VCAs consist of blocks of functional units comprising
different tissue types such as skin, bone, muscle, nerves, blood vessels,
tendons, ligaments and others, and are thus substantially different from the
composition of organ transplants. The field of VCA has made fascinating
progresses in the recent past. Among other VCAs, numerous successful hand, face
and limb transplants have been performed in the world. At the same time, specific
questions in regard to innate and adaptive immunity, consequences of
ischemia/reperfusion injury, immunosuppression, preservation, and regenerative
capacity remain. In spite of this, the field is poised to make significant
advances in the near future.