Current status of bicarbonate in CKD
#MMPMID25150154
Dobre M
; Rahman M
; Hostetter TH
J Am Soc Nephrol
2015[Mar]; 26
(3
): 515-23
PMID25150154
show ga
Metabolic acidosis was one of the earliest complications to be recognized and
explained pathologically in patients with CKD. Despite the accumulated evidence
of deleterious effects of acidosis, treatment of acidosis has been tested very
little, especially with respect to standard clinical outcomes. On the basis of
fundamental research and small alkali supplementation trials, correcting
metabolic acidosis has a strikingly broad array of potential benefits. This
review summarizes the published evidence on the association between serum
bicarbonate and clinical outcomes. We discuss the role of alkali supplementation
in CKD as it relates to retarding kidney disease progression, improving metabolic
and musculoskeletal complications.
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