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10.1097/MNH.0000000000000267 http://scihub22266oqcxt.onion/10.1097/MNH.0000000000000267 C5081243!5081243 !27584931     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27584931 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27584931 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Nephrol+Hypertens 2016 ; 25 (6 ): 556-562 Nephropedia Template TP {{tp|p=27584931 |t=2016. Current status of alloimmunity |pdf=|usr=}}{{27584931 }} gab.com Text Current status of alloimmunity JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=27584931 #FOAvip PURPOSE OF REVIEW: The present review aims to highlight the major recent advances in transplantation with regards to basic, translational, and clinical research. RECENT FINDINGS: We describe new concepts in understanding allorecognition and allospecificity of T cells, and discuss current challenges in targeting memory T cells, including the limitation of rodent disease models. From a clinical perspective, we highlight the advances in molecular biopsy characterization, which have expanded our knowledge of potential drivers of injury and may provide better parameters for patient risk stratification. We also highlight the dual role of innate immunity in both stimulating and regulating adaptive immunity, as well as novel insights into environmental exposures that may affect immune regulation, such as high-salt diet. Finally, we discuss advances in understanding humoral response and novel technologies, such as chimeric antigen receptors-engineered T cells, microparticle-based drug delivery, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) gene editing, that may provide intriguing and promising approaches to restrain alloimmunity. SUMMARY: Current advances in our understanding of the basic mechanisms of alloimmunity and their potential translation to clinical applications will permit the development of novel diagnostic and therapeutic strategies to improve long-term graft survival. Twit Text FOAVip Current status of alloimmunity ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=27584931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27584931 #FOAvip English Wikipedia <ref>{{Cite pmid|27584931 }}</ref> Current status of alloimmunity #MMPMID27584931 Borges TJ ; Murakami N ; Riella LV Curr Opin Nephrol Hypertens 2016[Nov]; 25 (6 ): 556-562 PMID27584931 show ga PURPOSE OF REVIEW: The present review aims to highlight the major recent advances in transplantation with regards to basic, translational, and clinical research. RECENT FINDINGS: We describe new concepts in understanding allorecognition and allospecificity of T cells, and discuss current challenges in targeting memory T cells, including the limitation of rodent disease models. From a clinical perspective, we highlight the advances in molecular biopsy characterization, which have expanded our knowledge of potential drivers of injury and may provide better parameters for patient risk stratification. We also highlight the dual role of innate immunity in both stimulating and regulating adaptive immunity, as well as novel insights into environmental exposures that may affect immune regulation, such as high-salt diet. Finally, we discuss advances in understanding humoral response and novel technologies, such as chimeric antigen receptors-engineered T cells, microparticle-based drug delivery, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) gene editing, that may provide intriguing and promising approaches to restrain alloimmunity. SUMMARY: Current advances in our understanding of the basic mechanisms of alloimmunity and their potential translation to clinical applications will permit the development of novel diagnostic and therapeutic strategies to improve long-term graft survival. |*Immunity, Cellular [MESH] |*Immunity, Humoral [MESH] |*Immunity, Innate [MESH] |*Kidney Transplantation [MESH] |CRISPR-Cas Systems [MESH] |Gene Editing [MESH] |Graft Rejection/*immunology/prevention & control [MESH] |Humans [MESH]Current status of alloimmunity (epmc).pdf DeepDyve Pubget Overpricing