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2015 ; 1
(ä): 15036-
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Current questions and possible controversies in autophagy
#MMPMID26682061
Lindqvist LM
; Simon AK
; Baehrecke EH
Cell Death Discov
2015[]; 1
(ä): 15036-
PMID26682061
show ga
Interest in autophagy has exploded over the last decade, with publications
highlighting crosstalk with several other cellular processes including secretion,
endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins
have also been implicated in other cellular processes independently of their
roles in autophagy, creating complexities in the interpretation of autophagy
(Atg) mutant gene data. Interestingly, this self-eating process is a survival
mechanism that can also promote cell death, but when and how autophagy may
'switch' its function is still under debate. Indeed, there are currently many
models of how autophagy actually influences cell death. In this review, we
highlight some outstanding questions and possible controversies in the autophagy
field.