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10.1042/EBC20170028 http://scihub22266oqcxt.onion/10.1042/EBC20170028 C5869234!5869234 !29118093     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29118093 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29118093 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Essays+Biochem 2017 ; 61 (5 ): 453-464 Nephropedia Template TP {{tp|p=29118093 |t=2017. Current perspectives in fragment-based lead discovery (FBLD) |pdf=|usr=}}{{29118093 }} gab.com Text Current perspectives in fragment-based lead discovery (FBLD) JO: Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29118093 #FOAvip It is over 20 years since the first fragment-based discovery projects were disclosed. The methods are now mature for most 'conventional' targets in drug discovery such as enzymes (kinases and proteases) but there has also been growing success on more challenging targets, such as disruption of protein-protein interactions. The main application is to identify tractable chemical startpoints that non-covalently modulate the activity of a biological molecule. In this essay, we overview current practice in the methods and discuss how they have had an impact in lead discovery - generating a large number of fragment-derived compounds that are in clinical trials and two medicines treating patients. In addition, we discuss some of the more recent applications of the methods in chemical biology - providing chemical tools to investigate biological molecules, mechanisms and systems. Twit Text FOAVip Current perspectives in fragment-based lead discovery (FBLD) ????Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29118093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29118093 #FOAvip English Wikipedia <ref>{{Cite pmid|29118093 }}</ref> Current perspectives in fragment-based lead discovery (FBLD) #MMPMID29118093 Lamoree B ; Hubbard RE Essays Biochem 2017[Nov]; 61 (5 ): 453-464 PMID29118093 show ga It is over 20 years since the first fragment-based discovery projects were disclosed. The methods are now mature for most 'conventional' targets in drug discovery such as enzymes (kinases and proteases) but there has also been growing success on more challenging targets, such as disruption of protein-protein interactions. The main application is to identify tractable chemical startpoints that non-covalently modulate the activity of a biological molecule. In this essay, we overview current practice in the methods and discuss how they have had an impact in lead discovery - generating a large number of fragment-derived compounds that are in clinical trials and two medicines treating patients. In addition, we discuss some of the more recent applications of the methods in chemical biology - providing chemical tools to investigate biological molecules, mechanisms and systems. |*Combinatorial Chemistry Techniques [MESH] |*Drug Design [MESH] |Biphenyl Compounds/chemical synthesis/therapeutic use [MESH] |Clinical Trials as Topic [MESH] |Drug Discovery/methods [MESH] |Humans [MESH] |Indoles/therapeutic use [MESH] |Molecular Docking Simulation [MESH] |Neoplasm Proteins/*antagonists & inhibitors/genetics/metabolism [MESH] |Neoplasms/*drug therapy/genetics/metabolism/pathology [MESH] |Nitrophenols/chemical synthesis/therapeutic use [MESH] |Piperazines/chemical synthesis/therapeutic use [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins B-raf/antagonists & inhibitors/genetics/metabolism [MESH] |Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors/genetics/metabolism [MESH] |Small Molecule Libraries/*chemical synthesis/therapeutic use [MESH] |Structure-Activity Relationship [MESH] |Sulfonamides/chemical synthesis/therapeutic use [MESH] |Thermodynamics [MESH]Current perspectives in fragment-based lead discovery (FBLD) (epmc).pdf DeepDyve Pubget Overpricing