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10.1016/j.apsb.2015.05.006 http://scihub22266oqcxt.onion/10.1016/j.apsb.2015.05.006 C4629408!4629408 !26579459     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26579459 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Pharm+Sin+B 2015 ; 5 (4 ): 300-9 Nephropedia Template TP {{tp|p=26579459 |t=2015. Current developments in pharmacological therapeutics for chronic constipation |pdf=|usr=}}{{26579459 }} gab.com Text Current developments in pharmacological therapeutics for chronic constipation JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579459 #FOAvip Chronic constipation is a common gastrointestinal disease severely affecting the patient?s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. Twit Text FOAVip Current developments in pharmacological therapeutics for chronic constipation ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26579459 #FOAvip English Wikipedia <ref>{{Cite pmid|26579459 }}</ref> Current developments in pharmacological therapeutics for chronic constipation #MMPMID26579459 Jiang C ; Xu Q ; Wen X ; Sun H Acta Pharm Sin B 2015[Jul]; 5 (4 ): 300-9 PMID26579459 show ga Chronic constipation is a common gastrointestinal disease severely affecting the patient?s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. äCurrent developments in pharmacological therapeutics for chronic const(epmc).pdf DeepDyve Pubget Overpricing