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2017 ; 46
(8
): 2038-2056
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Current detection technologies for circulating tumor cells
#MMPMID28393954
Shen Z
; Wu A
; Chen X
Chem Soc Rev
2017[Apr]; 46
(8
): 2038-2056
PMID28393954
show ga
Circulating tumor cells (CTCs) are cancer cells that circulate in the blood
stream after being naturally shed from original or metastatic tumors, and can
lead to a new fatal metastasis. CTCs have become a hotspot research field during
the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for
early diagnosis of cancers, earlier evaluation of cancer recurrence and
chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs.
Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we
classify the currently reported CTC detection technologies, introduce some
representative samples for each technology, conclude the advantages and
limitations, and give a future perspective including the challenges and
opportunities of CTC detection.