Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27367183
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27367183
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Invest
2016 ; 126
(7
): 2394-403
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Current concepts of severe asthma
#MMPMID27367183
Ray A
; Raundhal M
; Oriss TB
; Ray P
; Wenzel SE
J Clin Invest
2016[Jul]; 126
(7
): 2394-403
PMID27367183
show ga
The term asthma encompasses a disease spectrum with mild to very severe disease
phenotypes whose traditional common characteristic is reversible airflow
limitation. Unlike milder disease, severe asthma is poorly controlled by the
current standard of care. Ongoing studies using advanced molecular and
immunological tools along with improved clinical classification show that severe
asthma does not identify a specific patient phenotype, but rather includes
patients with constant medical needs, whose pathobiologic and clinical
characteristics vary widely. Accordingly, in recent clinical trials, therapies
guided by specific patient characteristics have had better outcomes than previous
therapies directed to any subject with a diagnosis of severe asthma. However,
there are still significant gaps in our understanding of the full scope of this
disease that hinder the development of effective treatments for all severe
asthmatics. In this Review, we discuss our current state of knowledge regarding
severe asthma, highlighting different molecular and immunological pathways that
can be targeted for future therapeutic development.
free
free
free
