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2017 ; 26
(7
): 258-266
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Current concepts in eosinophilic esophagitis
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Simon D
; Straumann A
; Schoepfer AM
; Simon HU
Allergo J Int
2017[]; 26
(7
): 258-266
PMID29104849
show ga
BACKGROUND: Eosinophilic esophagitis (EoE) is a disease entity first described in
the 1990s, but showing an increasing incidence that is characterized clinically
by esophageal dysfunction and histologically by a striking eosinophil
infiltration. METHODS: This article discusses new aspects of the pathogenesis,
symptoms, diagnosis, and treatment of EoE. RESULTS: EoE affects both children and
adults and is frequently associated with atopic disease and IgE sensitization.
Barrier dysfunction and T?helper 2 inflammation are considered to be
pathogenetically important factors. Recently, a proton pump inhibitor
(PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described.
CONCLUSION: Research in recent years has contributed to a better understanding of
the disease spectrum and pathogenesis of EoE, including genetic dispositions,
thereby laying the foundation for innovative treatment approaches.
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